LAUSR

BP: bullous pemphigoid LABD: linear IgA bullous dermatosis LAGBD: linear IgA/IgG bullous dermatosis INTRODUCTION Autoimmune subepidermal blistering diseases are caused by immunological loss of tolerance to components of hemidesmosomes, triggering humoral and cellular responses. C3 and IgG deposition along the basement membrane zone is characteristic of bullous pemphigoid (BP). Alternately, IgA deposition at the basement membrane zone is consistent with linear IgA bullous dermatosis (LABD). An immunological overlap spanning the clinical and immunologic spectrum between BP and LABD has been reported and referred to as linear IgA/IgG bullous dermatosis (LAGBD). LAGBD has a unique clinical presentation, immunologic properties, and distinct therapeutic options including rituximab.