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ED: emergency department MIS-A: multisystem inflammatory syndrome in adults PCR: polymerase chain reaction INTRODUCTION Since the emergence of SARS-CoV-2 worldwide, various manifestations and sequelae have been reported, including COVID-19-associated Kawasaki-like multisystem inflammatory syndrome in children. This dysregulated immune sequela often presents with features of hypotension or shock, cardiac dysfunction, arterial or venous thromboembolism, gastrointestinal discomfort, and protean skin manifestations. More recently, the Centers for Disease Control and Prevention has acknowledged an increasing incidence of multisystem inflammatory syndrome in adults (MIS-A). The diagnostic criteria for MIS-A includes individuals aged $ 21, positive SARS-CoV-2 testing indicating recent infection, multi-organ dysfunction without severe respiratory illness, and elevated inflammatory markers. We describe 2 adult patients with signs and symptoms compatible with MIS-A for which dermatologic findings were the presenting symptoms.