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Lesion reduction with intralesional deoxycholic acid in Dercum disease with radiographic evidence

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DCA: deoxycholic acid INTRODUCTION Dercum disease, also known as adiposis dolorosa, is a rare disorder characterized by multiple painful lipomas most often arising in women aged 35 to 50 years.… Click to show full abstract

DCA: deoxycholic acid INTRODUCTION Dercum disease, also known as adiposis dolorosa, is a rare disorder characterized by multiple painful lipomas most often arising in women aged 35 to 50 years. There are currently no approved treatments for Dercum disease. Therapies tried with variable efficacy for symptom management include analgesics, excision, and liposuction. For patients who continually develop widespread lesions, surgical excision is not feasible, posing a conundrum for patients and providers. Thus, the development of effective, less invasive therapies is needed. In this report, we suggest the use of intralesional deoxycholic acid (DCA) to mitigate pain and lipoma size in patients with Dercum disease and demonstrate radiographic evidence of the success of lipoma reduction in a patient.

Keywords: dercum disease; radiographic evidence; intralesional deoxycholic; deoxycholic acid

Journal Title: JAAD Case Reports
Year Published: 2021

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