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Long-term maintenance of eosinophilic dermatosis of hematologic malignancy with doxycycline

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BP: bullous pemphigoid CLL: chronic lymphocytic leukemia EDHM: eosinophilic dermatosis of hematologic malignancy INTRODUCTION Eosinophilic dermatosis of hematologic malignancy (EDHM) is a cutaneousmanifestation reported with various hematoproliferative and lymphoproliferative disorders,… Click to show full abstract

BP: bullous pemphigoid CLL: chronic lymphocytic leukemia EDHM: eosinophilic dermatosis of hematologic malignancy INTRODUCTION Eosinophilic dermatosis of hematologic malignancy (EDHM) is a cutaneousmanifestation reported with various hematoproliferative and lymphoproliferative disorders, most commonly chronic lymphocytic leukemia (CLL). It is characterized as a nonspecific pruritic eruption with pleomorphic clinical presentations ranging from erythematous, urticarial papules and nodules to vesicles and bullae, making accurate diagnosis difficult, as it can mimic other conditions. EDHM often has a chronic, recurrent course with differential responses to treatment modalities reported in the literature. We report two cases of EDHM that initially were a diagnostic and therapeutic challenge; we hope to raise awareness of this rare entity as well as share a successful long-term treatment regimen not previously reported.

Keywords: hematologic malignancy; dermatosis hematologic; eosinophilic dermatosis

Journal Title: JAAD Case Reports
Year Published: 2021

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