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DVT: deep venous thrombosis IL: interleukin LLE: left lower extremity PG: pyoderma gangrenosum INTRODUCTION Pyoderma gangrenosum (PG) is an ulcerative neutrophilic dermatosis that classically affects the lower extremities. The pathophysiology… Click to show full abstract
DVT: deep venous thrombosis IL: interleukin LLE: left lower extremity PG: pyoderma gangrenosum INTRODUCTION Pyoderma gangrenosum (PG) is an ulcerative neutrophilic dermatosis that classically affects the lower extremities. The pathophysiology of PG is incompletely understood, which makes targeted therapeutic approaches challenging. Interleukin (IL) 23, a cytokine implicated in neutrophilic diseases, has shown promise as a PG treatment target. We report a case of recalcitrant PG treated with guselkumab (an IL-23 inhibitor) at a dose modified from that approved for other inflammatory conditions.
Journal Title: JAAD Case Reports
Year Published: 2022
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