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Abstract In the present investigation we explore the ex vivo and in vivo cancer targeting potential of Doxorubicin laden oxidized dextran conjugated PEG-multi walled carbon nanotubes (DOX/ox-DEX/PEG-MWCNTs) using MCF-7 cells. The percent entrapment… Click to show full abstract
Abstract In the present investigation we explore the ex vivo and in vivo cancer targeting potential of Doxorubicin laden oxidized dextran conjugated PEG-multi walled carbon nanotubes (DOX/ox-DEX/PEG-MWCNTs) using MCF-7 cells. The percent entrapment efficiency was found to be 97.00 ± 2.10% (DOX/ox-DEX/PEG-MWCNTs) and 92.00± 3.00% (DOX/MWCNTs). The DOX/ox-DEX/PEG-MWCNTs depicted enhanced cellular uptake and cytotoxicity. The obtained results also showed the extended residence time of DOX/ox-DEX/PEG-MWCNTs as compared to DOX/MWCNTs and free DOX. Overall, we can conclude that the developed Doxorubicin loaded functionalized MWCNTs could be explored successfully for cancer targeting propensity.
Journal Title: Journal of Drug Delivery Science and Technology
Year Published: 2017
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