LAUSR

Abstract Praziquantel (PZQ) is an anthelmintic of choice in the treatment of schistosomiasis. Solvent evaporation technique produced three different Solid Dispersions (SD) (drug: polymer, w/w) with sodium alginate (ALG) or carboxymethylcellulose (CMC). Characterization was done by X-Ray Diffraction (XRD), Fourier Transformed Infrared spectroscopy (FTIR) and Scanning Electron Microscopy (SEM), thermal analysis (DSC/TG), cell viability and in vitro assay against S. mansoni . The results of SD with different ratios revealed that the 1:0.25 ratio of PZQ with ALG showed higher solubility. The morphological structure change to the lamellar structure that it was confirmed with XRD. Then, thermal analyses and FTIR indicating a significant interaction between PZQ and polymer in SD indicate a change in the molecular mobility of the drug. In a culture of S. mansoni , we observed that SD is leading the death of the parasites. Regarding cytotoxicity, SD does not show toxicity in fibroblasts cells.