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Abstract With a view to design a drug delivery vehicle for the sustained release of Rifampicin (RIF) – an anti-tuberculosis drug, the present work reports the synthesis of poly (o-anisidine-co-o-toluidine)… Click to show full abstract
Abstract With a view to design a drug delivery vehicle for the sustained release of Rifampicin (RIF) – an anti-tuberculosis drug, the present work reports the synthesis of poly (o-anisidine-co-o-toluidine) (PAnis-co-POT) intercalated bentonite nanocomposites via ultrasound-assisted technique. Intercalation as well as copolymerization was confirmed by FT-IR, UV-visible, X-ray diffraction, (XRD). Loading of the copolymer in benotnite clay was confirmed by and thermogravimetric analysis (TGA). Rifampicin (RIF) drug was loaded into the nanocomposite and the release profiles were investigated in gastric (pH 1.2) and intestinal (pH 7.4) fluids. Release followed the zero order kinetics model. The nanocomposites were found to show the sustained release behavior and hold potential to be used as an effective anti-tuberculosis drug delivery vehicle.
Journal Title: Journal of Drug Delivery Science and Technology
Year Published: 2018
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