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Abstract Resveratrol (RES) shows excellent pharmacological activities but is limited by a very short half-life. In this study, red blood cell (RBC) membranes camouflaging RES-loaded PLGA NPs (RBC-RES-NPs) were successfully… Click to show full abstract
Abstract Resveratrol (RES) shows excellent pharmacological activities but is limited by a very short half-life. In this study, red blood cell (RBC) membranes camouflaging RES-loaded PLGA NPs (RBC-RES-NPs) were successfully designed and synthesized. The resulting RBC-RES-NPs were spherical and had a clear core-shell structure with an average size of 148.1 ± 1.1 nm and a negatively charged surface of −18.20 ± 0.73 mV. The entrapment efficiency and drug loading rate were 96.51 ± 1.29% and 1.79 ± 0.02%, respectively. The diameter and distribution of the RBC-RES-NPs were largely stable for 7 consecutive days. Compared with that of RES and the RES-NPs, a remarkably sustained release effect was observed in the RBC-RES-NP group, with a cumulative release rate of approximately 60% after 2 h of measurement time. After systemic injection in rats, the half-life of the RBC-RES-NPs (10.34 ± 1.40 min) was distinctly longer than that of RES (7.50 ± 1.00 min, p
Journal Title: Journal of Drug Delivery Science and Technology
Year Published: 2019
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