Abstract The fibrous silicates, Palygorskite and Sepiolite, were investigated as low-cost nanocarriers for three carvacrol prodrugs to ameliorate their pharmacokinetic and biopharmaceutic profiles. Adsorption equilibrium studies were performed in order… Click to show full abstract
Abstract The fibrous silicates, Palygorskite and Sepiolite, were investigated as low-cost nanocarriers for three carvacrol prodrugs to ameliorate their pharmacokinetic and biopharmaceutic profiles. Adsorption equilibrium studies were performed in order to obtain a drug-clay hybrid system. These hybrid systems were characterized by thermal analysis, X-ray diffraction, and Fourier transform infrared spectroscopy, to study the degree and kind of interactions between the organic and inorganic components. In vitro release and chemical stability of prodrug-clay hybrids were studied in physiological gastrointestinal simulated fluids. The results showed an improvement of the chemical stability of prodrugs in hybrids systems, as well as a sustained release and a retained bioconversion of the prodrugs into the pharmacologically active carvacrol, to improve the antimicrobial activity.
               
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