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BACKGROUND There are a number of hypotheses about the link between sensitive skin and skin microbiota, but so far there have been no studies to confirm these. OBJECTIVE To answer whether the sensitive skin microbiome is distinct from that of no-sensitive skin. METHOD By bacterial 16s rRNA gene sequencing, analyzed the difference of microbial composition cheek skin in young women aged 18 to 25 years old between sensitive and non-sensitive skin. RESULT On the whole, there was no significant difference in skin bacterial diversity (Shannon index) and richness (sobs and Chao index) between SS group and NS group (p > 0.05). However, further analysis showed that the relative abundance of Staphylococcus decreased significantly in SS group. The abundance of Staphylococcus is second only to Propionibacterium in facial cheeks of normal and sensitive skin. The results of species level analysis showed that, the abundance of Staphylococcus aureus limited increased, while that of Staphylococcus epidermidis decreased significantly in SS group. CONCLUSION The occurrence of sensitive skin is related to the weak microbial barrier associated with the significant decrease of Staphylococcus epidermidis.