LAUSR

It is widely agreed that virtually all cosmetic volumizer agents can sometimes induce nodule formation. Here, we reported a case of cosmetic materials-induced foreign body granuloma presenting as a subcutaneous nodule at the left lower lip of a 61-year-old female patient. This 61-year-old male patient came to our dental clinic for evaluation and treatment of a subcutaneous nodule at the left lower lip for more than 2 months. The nodule was tender, elastic, and palpable at the subcutaneous area of the left lower lip. It measured approximately 0.8 cm in greatest dimension. The clinical diagnosis was either a mucocele or a lipoma. After discussing with the patient and obtaining the signed informed consent, the nodule was totally excised under local anesthesia. The removed soft tissue specimen was sent for histopathological examination. Microscopically, it showed several micronodules of granulomatous fibrous connective tissues containing epithelioid macrophages, multinucleated foreign body giant cells, lymphocytes, and evenly distributed foreign body materials presenting as thin band-like or spindleshaped spaces dispersed among the muscle bundles and adjacent to the minor labial glands (Fig. 1A-D). On mediumand high-power views, the thin band-like or spindleshaped foreign body materials were mainly surrounded by multinucleated foreign body giant cells, and the macrophages and lymphocytes were discovered at the peripheral areas of the multinucleated foreign body giant cells in the granulomatous fibrous connective tissues (Fig. 1E-G). By