LAUSR

Abstract A novel electrochemical sensor was designed and constructed for high-sensitive detection of Taxifolin based on Co3S4@MoS2 loaded on reduced graphene oxide (RGO-Co3S4@MoS2) as modified materials. It’s the first time for Co3S4@MoS2 was exploited to constructed electrochemical sensor. Owing to the Co3S4@MoS2 providing a huge surface area to enrich more Taxifolin and the excellent electric conductivity of RGO, Taxifolin was detected sensitively with a linear range from 5.0 × 10 −9 to 1.0 × 10−6 mol L−1 and limit of detection down to 1.67 × 10−9 mol L−1 (S/N = 3). In addition, the sensor also demonstrated strong anti-interference properties in the presence of some metal ions and organic compounds. The proposed method was successfully applied for determination of Taxifolin in traditional Chinese medicine in fructus polygoni orientalis with satisfactory results.