LAUSR

Abstract Bimetallic nanoparticles combined with 2D boron nitride shows an effective approach towards the fabrication of an efficient electrocatalyst with excellent physicochemical and electrochemical properties. This work describes the synthesis of iron vanadate nanoparticles (FeVO4 NPs) supported on boron nitride (hBN) nanocomposite through hydrothermal synthesis followed by a solvent evaporation method for the ultra-sensitive electrochemical determination of chlorpromazine (CPZ). The nanocomposite was analyzed by typical characterization techniques such as X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FT-IR), field emission scanning electron microscope (FE-SEM), transmission electron microscope (TEM), X-ray photoelectron spectroscope (XPS), and Brunauer–Emmett–Teller (BET) analysis to confirm the crystalline phase, structural morphology, and surface area of the as-prepared nanocomposite. Under optimized voltammetric conditions, FeVO4 NPs/30 hBN modified screen-printed carbon electrode (FeV NPs/30 hBN/SPCE) shows a wide linear concentration from 0.04 to 2222.1 μM, a lower detection limit of 0.004 μM with a sensitivity of 0.84 μA μM−1 cm−2. The as-proposed electrode demonstrated excellent stability, reproducibility, and selectivity in the presence of potentially interfering active compounds towards the detection of CPZ. Furthermore, the practicality was successfully demonstrated in human urine and serum samples with satisfactory results.