LAUSR.org creates dashboard-style pages of related content for over 1.5 million academic articles. Sign Up to like articles & get recommendations!

Dietary flaxseed oil improved western-type diet-induced atherosclerosis in apolipoprotein-E knockout mice

Photo by primal_harmony from unsplash

Abstract Flaxseed oil is a rich source of n-3 fatty acid alpha-linolenic acid which has been identified as having significant cardioprotective effects. The objective of this study was to investigate… Click to show full abstract

Abstract Flaxseed oil is a rich source of n-3 fatty acid alpha-linolenic acid which has been identified as having significant cardioprotective effects. The objective of this study was to investigate the effect of partial replacement of lard with flaxseed oil on atherosclerosis and investigate the underlying mechanisms. Apolipoprotein-E knockout mice were given a normal chow diet, a lard based western-type high-fat diet (WTD), or a WTD with partial replacement of lard with 10% flaxseed oil (w/w) for 16 weeks, respectively. Results demonstrated that partial replacing of lard with flaxseed oil significantly ameliorated atherosclerosis, as well as improved lipid abnormalities, oxidative stress, and inflammation. These data were associated with modification effects on expression of genes involved in lipid metabolism (SREBP-2, HMGCR, SREBP-1c, and ACC), oxidative stress (NADPH oxidase), and inflammation (TNF-α, IL-6, MCP-1, and VCAM-1). Our data providing evidence that flaxseed oil could be a promising functional food in cardiovascular health promotion.

Keywords: western type; flaxseed oil; knockout mice; apolipoprotein knockout; atherosclerosis; oil

Journal Title: Journal of Functional Foods
Year Published: 2018

Link to full text (if available)


Share on Social Media:                               Sign Up to like & get
recommendations!

Related content

More Information              News              Social Media              Video              Recommended



                Click one of the above tabs to view related content.