LAUSR

Abstract Natural products can be very effective in the prevention of obesity-related metabolic disorders. The aim of the present study was to investigate the anti-obesity effects of Aloe vera (Aloe barbadensis Miller) gel administration at 100 and 200 mg/kg/day, in a diet-induced obesity rat model. The whole gel was used. Plasma and tissue parameters and adipose lipase activities were determined. Our results emphasized that obese rats displayed dyslipidemia and stress oxidative, with excessive adipose tissue lipids. Aloe vera gel administration at 100 and 200 mg/kg/day prevented adipose tissue accumulation and corrected the dyslipidemia and oxidative stress. In addition, it induced adipose LPL inhibition and HSL activation in obese rats. In conclusion, Aloe vera reduced fat accumulation via its protective role against obesity-related metabolic alterations and antioxidant effects. Aloe vera has great potential as functional foods in the activation adipose lipolysis and the prevention of obesity-related metabolic alterations.