LAUSR

Abstract Procyanidins are a group of flavonoids that can be found in many plants. The objective of the current study was to investigate the anti-obesity effect of procyanidin on high fat diet induced obese C57BL/6J mice. The mice were administrated with 100 mg/kg procyanidin for 12 weeks. The results showed that consumption of procyanidin significantly ameliorated high fat diet induced obesity and its associated risk factors, including reduction of body weight gain, lipid profile improvement and increase of energy expenditure. Moreover, microbial 16S rRNA gene sequencing of the feces demonstrated that procyanidin administration markedly increased intestinal microbiota β diversity and Bacteroidetes quantities but decreased the Firmicutes/Bacteroidetes ratio. We conclude that supplementation with procyanidin prevents obesity and modifies the gut microbiota composition.