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Abstract The objective of this study was to determine the effects of watermelon on colitis in rats treated with Dextran Sodium Sulfate (DSS) and high-fat diet. We hypothesized that watermelon… Click to show full abstract
Abstract The objective of this study was to determine the effects of watermelon on colitis in rats treated with Dextran Sodium Sulfate (DSS) and high-fat diet. We hypothesized that watermelon would reduce colitis severity by maintaining the number of intact crypts and regulating cell homeostasis. Forty rats were divided into four groups: control diet, control diet + DSS, 0.33% watermelon powder diet, and 0.33% watermelon powder diet + DSS. After 4 weeks of defined diets, DSS group rats were administered 3% (w/v) DSS (40 kDa) in their drinking water for 2 days. DSS administration increased colonocyte proliferation and apoptosis while decreasing cell differentiation and the number of intact colonic crypts (P
Journal Title: Journal of Functional Foods
Year Published: 2019
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