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Nucleophilic monofluoroalkylation with fluorinated phosphonium salt toward carbonyl and imine compounds

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Abstract A fluorinated substituent on the positive phosphorus in phosphonium salt [Ph3P+CF(Me)CO2Et Br−] was found to be able to act as a nucleophile to realize monofluoroalkylation of aldehydes, ketones and… Click to show full abstract

Abstract A fluorinated substituent on the positive phosphorus in phosphonium salt [Ph3P+CF(Me)CO2Et Br−] was found to be able to act as a nucleophile to realize monofluoroalkylation of aldehydes, ketones and imines.

Keywords: monofluoroalkylation fluorinated; nucleophilic monofluoroalkylation; phosphonium salt; phosphonium

Journal Title: Journal of Fluorine Chemistry
Year Published: 2017

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