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Abstract We report an efficient synthetic method for CF 3 -containing oxazolines via trifluoromethylation of allylamides by using Togni reagent in the presence of alkali metal iodides, which play a… Click to show full abstract
Abstract We report an efficient synthetic method for CF 3 -containing oxazolines via trifluoromethylation of allylamides by using Togni reagent in the presence of alkali metal iodides, which play a key role in selective production of the desired oxazoline. The reaction did not proceed efficiently with copper catalysts commonly used for oxytrifluoromethylations. Our method afforded a wide variety of CF 3 -containing oxazolines, which are potential candidates for pharmaceuticals, agrochemicals, and functional materials.
Journal Title: Journal of Fluorine Chemistry
Year Published: 2017
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