Abstract Multi-component Mannich reactions between 2-fluoro-ethylacetoacetate or dimethyl-2-fluoromalonate ester, aldehyde and amine components allowing convenient synthesis of β-fluoro(dicarbonyl)ethylamine systems using both batch and continuous flow techniques are reported. Click to show full abstract
Abstract Multi-component Mannich reactions between 2-fluoro-ethylacetoacetate or dimethyl-2-fluoromalonate ester, aldehyde and amine components allowing convenient synthesis of β-fluoro(dicarbonyl)ethylamine systems using both batch and continuous flow techniques are reported.
Keywords:
ethylacetoacetate dimethyl;
dimethyl fluoromalonate;
fluoromalonate ester;
component mannich;
mannich reactions;
fluoro ethylacetoacetate
Journal Title: Journal of Fluorine Chemistry
Year Published: 2018
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Journal Title: Journal of Fluorine Chemistry
Year Published: 2018
Link to full text (if available)
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recommendations!