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Abstract A facile enantioselective addition of terminal 3-en-1-ynes to cyclic N-acyl trifluoromethyl ketimines is reported. In the presence of Zinc/BINOL complexes, a series of enynylated tertiary carbinamines were readily obtained… Click to show full abstract
Abstract A facile enantioselective addition of terminal 3-en-1-ynes to cyclic N-acyl trifluoromethyl ketimines is reported. In the presence of Zinc/BINOL complexes, a series of enynylated tertiary carbinamines were readily obtained in 90–97% yield with 70–97% enantiomeric excess in a single chemical operation under mild reaction conditions.
Keywords:
enantioselective addition;
ynes cyclic;
trifluoromethyl ketimines;
addition terminal;
terminal ynes
Journal Title: Journal of Fluorine Chemistry
Year Published: 2018
Link to full text (if available)
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Journal Title: Journal of Fluorine Chemistry
Year Published: 2018
Link to full text (if available)
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recommendations!