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Abstract Unprecedented isobenzofuran-1-ones (phthalides) with CF3 and ethoxy groups both at the 3-position were readily synthesized from the corresponding aromatic 1,2-diesters and reacted with a variety of primary amines to… Click to show full abstract
Abstract Unprecedented isobenzofuran-1-ones (phthalides) with CF3 and ethoxy groups both at the 3-position were readily synthesized from the corresponding aromatic 1,2-diesters and reacted with a variety of primary amines to find out convenient conversion to the corresponding γ-lactams, while secondary amines behaved in a totally different manner to affect the net substitution reactions for the EtO moiety, where characteristics of the strongly electron-withdrawing CF3 group was considered to play a significantly important role.
Journal Title: Journal of Fluorine Chemistry
Year Published: 2019
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