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Abstract The fluorination of 6-substituted 2-aminopyrazines with Selectfluor in the presence of Ag2CO3 is established under mild conditions. This method selectively produced the fluorinated 2-aminopyrazine derivatives in fair to high… Click to show full abstract
Abstract The fluorination of 6-substituted 2-aminopyrazines with Selectfluor in the presence of Ag2CO3 is established under mild conditions. This method selectively produced the fluorinated 2-aminopyrazine derivatives in fair to high yield. The regioselectivity of this reaction strongly depends upon the substituent on the 2-aminopyrazines. The transformation of the fluorinated 2-aminopyrazine 3 h into a bioactive compound was discussed as well.
Keywords:
fluorination substituted;
substituted amionpyrazines;
chemistry;
fluorination;
selective fluorination;
catalyzed selective
Journal Title: Journal of Fluorine Chemistry
Year Published: 2019
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Journal Title: Journal of Fluorine Chemistry
Year Published: 2019
Link to full text (if available)
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recommendations!