Photo by jakobowens1 from unsplash
Abstract A copper-catalyzed tandem cyclization and vinylation of 2-chloro-1-(2-bromoaryl)-3,3,3-trifluoropropenes with KOH has been developed for the synthesis of 2-trifluoromethyl benzofuran derivatives. The reaction involves dual C O bonds formation and… Click to show full abstract
Abstract A copper-catalyzed tandem cyclization and vinylation of 2-chloro-1-(2-bromoaryl)-3,3,3-trifluoropropenes with KOH has been developed for the synthesis of 2-trifluoromethyl benzofuran derivatives. The reaction involves dual C O bonds formation and hydroarylation of aryl trifluoropropynes. This approach represents a simple and efficient one-pot synthesis of 2-trifluoromethy-3-vinylbenzofurans, which are potentially useful in drug design.
Keywords:
tandem cyclization;
cyclization vinylation;
catalyzed tandem;
synthesis trifluoromethyl;
synthesis;
copper catalyzed
Journal Title: Journal of Fluorine Chemistry
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Journal of Fluorine Chemistry
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!