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Ligand-free palladium-catalyzed Mizoroki-Heck reaction to synthesize valuable α-trifluoromethylacrylates

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Abstract α-Trifluoromethylacrylates were synthesized using efficient ligand-free palladium catalyzed Mizoroki-Heck reaction. With the alkyl trifluoromethylacrylates used as substrates, different catalytic systems were explored including Pd/C as a catalyst. Good to… Click to show full abstract

Abstract α-Trifluoromethylacrylates were synthesized using efficient ligand-free palladium catalyzed Mizoroki-Heck reaction. With the alkyl trifluoromethylacrylates used as substrates, different catalytic systems were explored including Pd/C as a catalyst. Good to excellent yields were obtained with good chemical tolerance.

Keywords: catalyzed mizoroki; ligand free; palladium catalyzed; heck reaction; free palladium; mizoroki heck

Journal Title: Journal of Fluorine Chemistry
Year Published: 2020

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