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Continuous microfluidic production of zein nanoparticles and correlation of particle size with physical parameters determined using CFD simulation

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Abstract Zein nanoparticles (NPs) were generated using continuous microfluidic antisolvent precipitation. Concentrations of ethanol and zein, flow ratio between continuous and dispersed phases, total flow rate, and chip configuration were… Click to show full abstract

Abstract Zein nanoparticles (NPs) were generated using continuous microfluidic antisolvent precipitation. Concentrations of ethanol and zein, flow ratio between continuous and dispersed phases, total flow rate, and chip configuration were examined for their effect on NP diameter and polydispersity index (PDI). These conditions were simulated using COMSOL Multiphysics and the diameter and PDI of NPs were correlated with physical parameters calculated by the software. Increasing zein and ethanol concentration increased NP diameter overall (p

Keywords: production zein; microfluidic production; physical parameters; zein; zein nanoparticles; continuous microfluidic

Journal Title: Journal of Food Engineering
Year Published: 2017

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