LAUSR

An overview of the literature was conducted to assess prevalence and mechanisms of antibiotic resistance to date, mainly to β-lactam antibiotics, cephalosporins, carbapenems, colistin and tigecycline in DR Congo. English and French publications were listed and analysed using PubMed/Medline, Google Scholar and African Journals database between January 1st, 1990 and December 31, 2019. For the 30 published articles found: i) Bacterial resistance to antibiotics concerned both Gram-negative and Gram-positive bacteria; ii) Multidrug resistance prevalence was the same in half of Streptococcus pneumoniae isolates; iii) A worrying prevalence of methicillin-resistant Staphylococcus aureus (MRSA) was noted, associated with co-resistance to several other antibiotics; iv) Resistance to 3rd generation cephalosporins was very high in Enterobacteriaceae, mainly due to blaCTX-M-1 group and blaSHV genes. Data on carbapenem and colistin resistance were not available until now. Further work is required to set up a surveillance system for antibiotic resistance in this country.