LAUSR

INTRODUCTION Limited data are reported regarding osteomyelitis due to Carbapenemase-producing Enterobacteriaceae (CPE), including co-infections with Extended-Spectrum Beta-Lactamase (ESBL) microorganisms. METHODS We conducted a retrospective study in a reference center for bone and joint infection (BJI) from 2011 to 2019 among patients infected by CPE. RESULTS Nine patients, mean age of 46.8 ± 16.6 years -including 3 infected implants- were identified. Infections were mostly polymicrobial (n = 8/9), including S. aureus (n = 5/9). CPE were mainly OXA-48-type, associated with ESBL-producing Enterobacteriaceae (n = 8/9), of which 5/9 isolates were K. pneumoniae (n = 5/9). Control of the infection was achieved in 7/9 cases. CONCLUSION CPE osteomyelitis are essentially polymicrobial and fluoroquinolones-resistant infections, highlighting the need of efficient surgery with implant removal.