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OBJECTIVES This study aimed to characterize insertional mutations disturbing mgrB in carbapenem-resistant K. pneumoniae (CRKp). METHODS One hundred eighteen clinical CRKp strains were surveyed for polymyxin resistance and insertion sequences… Click to show full abstract
OBJECTIVES This study aimed to characterize insertional mutations disturbing mgrB in carbapenem-resistant K. pneumoniae (CRKp). METHODS One hundred eighteen clinical CRKp strains were surveyed for polymyxin resistance and insertion sequences (IS) disrupting mgrB. RESULTS Seventy-eight (66%) strains displayed polymyxin resistance, of which 53% (42/78) had IS::mgrB inserts. Sequencing analyses showed 13 insertion sites in mgrB. For the first time, ISsen4(IS3)::mgrB was observed in CRKp. CONCLUSIONS Ten different ISs disrupted mgrB with predominance (76%) of IS5 sequences.
Journal Title: Journal of global antimicrobial resistance
Year Published: 2020
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