LAUSR

OBJECTIVES The study aimed to evaluate four selective serotonin reuptake inhibitors (SSRIs) as modifiers of fluconazole activity against resistant strains of Candida glabrata. METHODS SSRIs effect on fluconazole activity was studied using checkerboard method against C. glabrata strains (CBS 138, CBS 850821, DSY 562, DSY 565, ATCC 22553 and ATCC 90030); fractional inhibitory concentration index (FIC) was calculated and time-kill curve was used for the most prominent combination for further evaluation. RESULTS All used SSRIs have antifungal activity against C. glabrata strains tested. Combination of fluconazole with fluoxetine or fluvoxamine showed indifferent effects (FICI in all strains > 1 but <4), while paroxetine-fluconazole combination showed additive effect against DSY565 and CBS138, known to express efflux pumps as well as on ATCC strain (0.5