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Abstract MicroRNA-34a (miR-34a) suppression can block the progression of type II collagen decrease in chondrocytes for osteoarthritis (OA) treatment. Thus, exosomes, nano-sized extracellular vesicles, were developed as delivery vehicles for… Click to show full abstract
Abstract MicroRNA-34a (miR-34a) suppression can block the progression of type II collagen decrease in chondrocytes for osteoarthritis (OA) treatment. Thus, exosomes, nano-sized extracellular vesicles, were developed as delivery vehicles for antisense miR-34a locked nucleic acid (LNA). As a result, antisense LNA-loaded exosomes exhibited no cytotoxic effects on the chondrocytes and inhibited IL-1β-mediated type II collagen decrease in inflammation-induced chondrocytes. Moreover, the suppression of chondrocyte growth was inhibited upon antisense LNA-loaded exosome treatment. In conclusion, the exosome-mediated antisense delivery approach was shown to be biocompatible and functional as a highly efficient OA treatment and could be applicable for treating other diseases.
Journal Title: Journal of Industrial and Engineering Chemistry
Year Published: 2019
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