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OBJECTIVE To demonstrate the application of surgical neuroanatomic principles for the diagnosis and treatment of deep infiltrating endometriosis involving lateral femoral cutaneous nerve DESIGN: : video demonstration of laparoscopic lateral femoral cutaneous endometriosis resection with nerve transplant. SETTING Endometriosis infiltrating somatic nerves is a poorly known condition, which can cause severe neuropathic symptoms [1] and is often unrecognized with a subsequent treatment delay [1]. Intimate knowledge of pelvic neuroanatomy and expertise in minimally invasive surgery are essential to manage this challenging surgical scenario [2-4]. INTERVENTIONS A 36-year-old patient with primary infertility and chronic pelvic pain associated to dysmenorrhea, dyspareunia, dysuria, dyschezia. Preoperative MRI detected a 3 cm parauterine and 2 cm retrocervical endometetriosis nodules.  MRI did not demonstrate pelvic nerves involvement. Preoperative neuropelveological assessment demonstrated a significant hypoesthesia of the corresponding lateral femoral cutaneous nerve (LFCN) dermatome, representing the primary complaint. The swab-test showed spotting areas of allodynia. These findings prompted us to investigate for a right lateral femoral cutaneous entrapment. Laparoscopy showed an endometriosis nodule infiltrating right lateral femoral cutaneous nerve. A resection of the nerve was necessary and a subsequent reconstruction with a collagen bovine neuro-guide was carried out. The operative time was 300 minutes and the estimated blood was 150 mL. Hospital stay was 3 days. After three months the patient showed a clinical improvement in the pain and hypoesthesia on the reconstructed nerve dermatome. CONCLUSION Neuro-pelvic anatomical assessment should be considered during the pre-operative evaluation for endometriosis patients with pelvic pain and neuropathy as part of the diagnostic process [5]. This unique case demonstrates that nerve resection and transplantation can be used in specific situations for neuropathy related to deep infiltrative endometriosis of pelvic nerves.