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Abstract Recent in vitro and small-animal studies have demonstrated that anti-cancer efficiency of the emerging nanomedical technology of local magnetic hyperthermia can be essentially enhanced by concurrent chemotherapy. So far,… Click to show full abstract
Abstract Recent in vitro and small-animal studies have demonstrated that anti-cancer efficiency of the emerging nanomedical technology of local magnetic hyperthermia can be essentially enhanced by concurrent chemotherapy. So far, this encouraging result has been obtained in magnetic field conditions inapplicable to human body. In this article we report on magnetic hyperthermia system that proved capability of effective treatment of tumors in small-animals by the means of chemotherapy enhanced thermal ablation with the use of magnetic fields applicable to any part of human body. It is based on the rejection of traditional superparamagnetic nanoparticles in favor of hard magnetic particles, optimized taking into account the identified physiological and physical limitations.
Journal Title: Journal of Magnetism and Magnetic Materials
Year Published: 2019
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