LAUSR

BACKGROUND Human cortical primary sulci are relatively stable landmarks and commonly observed across the population. Despite their stability, the primary sulci exhibit phenotypic variability. NEW METHOD We propose a fully automated pipeline that integrates both sulcal curve extraction and labeling. In this study, we use a large normal control population (n = 1424) to train neural networks for accurately labeling the primary sulci. Briefly, we use sulcal curve distance map, surface parcellation, mean curvature and spectral features to delineate their sulcal labels. We evaluate the proposed method with 8 primary sulcal curves in the left and right hemispheres compared to an established multi-atlas curve labeling method. RESULTS Sulcal labels by the proposed method reasonably well agree with manual labeling. The proposed method outperforms the existing multi-atlas curve labeling method. COMPARISON WITH EXISTING METHOD Significantly improved sulcal labeling results are achieved with over 12.5 and 20.6 percent improvement on labeling accuracy in the left and right hemispheres, respectively compared to that of a multi-atlas curve labeling method in eight curves (p≪0.001, two-sample t-test). CONCLUSION The proposed method offers a computationally efficient and robust labeling of major sulci.