LAUSR

INTRODUCTION The aim of the present systematic review and meta-analysis was to compare the reported ADC values in different meningiomas and to analyze associations between ADC and cell count and proliferation activity in this tumor entity. METHOD MEDLINE library and SCOPUS database were screened for papers investigating ADC values of meningiomas up November 2019. The first primary endpoint of the systematic review was the reported ADC mean value of the meningioma groups. The second primary endpoint was the correlation coefficient between ADC values and proliferation index Ki 67 and cellularity. RESULTS For the discrimination analysis between benign and high grade meningioma 17 studies were suitable. There were 766 grade I tumors and 289 high grade meningiomas. The calculated mean ADC value of the benign grade I tumors was 0.93 × 10-3mm2/s [95%-Confidence interval 0.84;1.03] and the mean value of the high-grade tumors was 0.77 × 10-3mm2/s [95%-Confidence interval 0.73-0.80]. The pooled correlation coefficient between ADC and the proliferation index Ki 67 was r = -0.36 [95% CI -0.43; -0.28]. The pooled correlation coefficient between ADC and cellularity was r = -0.43 [95% CI -0.61; - 0.26]. CONCLUSION No validated ADC threshold can be recommended for distinguishing benign from high grade meningiomas. Only a moderate inverse correlation was identified between ADC values and tumor microstructure in meningiomas and, therefore, ADC might not accurately enough to predict proliferation potential and cellularity in this entity.