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Objectives: SM04755, a novel, topical, small molecule Wnt pathway inhibitor, has previously been shown to inhibit inflammation, reduce fibrosis, and increase tenocyte differentiation in nonclinical models. Two further experiments are… Click to show full abstract
Objectives: SM04755, a novel, topical, small molecule Wnt pathway inhibitor, has previously been shown to inhibit inflammation, reduce fibrosis, and increase tenocyte differentiation in nonclinical models. Two further experiments are presented: 1. SM04755 treatment in an acute dose-response tendinopathy model and 2. SM04755 treatment in a repeat injury/delayed treatment (RIDT) tendinopathy model. These models simulate acute and acute-on-chronic clinical tendinopathy, respectively.
Keywords:
inhibitor;
small molecule;
treatment;
topical small;
wnt pathway
Journal Title: Osteoarthritis and Cartilage
Year Published: 2018
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Journal Title: Osteoarthritis and Cartilage
Year Published: 2018
Link to full text (if available)
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recommendations!