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Design, synthesis and fungicidal activity studies of 3-ferrocenyl-N-acryloylmorpholine

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Abstract Ferrocene and its derivatives have been widely used in many fields and also used to modify and improve the performance. Particularly, their low toxicity also attract much attention in… Click to show full abstract

Abstract Ferrocene and its derivatives have been widely used in many fields and also used to modify and improve the performance. Particularly, their low toxicity also attract much attention in medical and pesticide fields. In order to get fungicides with higher biological activity, ferrocenyl groups were introduced into the skeleton of dimethomorph instead of phenyl groups and a series of 3-ferrocenyl- N -acryloylmorpholine were synthesized. The fungicidal bioassay results indicated that most of compounds showed moderate fungicidal activities against 14 kinds of agricultural pathogenic fungi and some compounds displayed higher fungicidal activities than that of dimethomorph. Intrestlingly, compounds 5(Z) exhibited better fungicidal activity against Sclerotinia sclerotiorum than that of compound 5( E ) .

Keywords: design synthesis; ferrocenyl acryloylmorpholine; fungicidal; fungicidal activity; synthesis fungicidal; activity

Journal Title: Journal of Organometallic Chemistry
Year Published: 2018

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