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Abstract The synthesis of an unsymmetrical silyl-ether-modified 1-oxazolinyl 1,2′-bis(diphenylphosphine) ferrocene is proposed herein. The designed 1,2′-bisphosphine is generated from 1-bromo-l’-carboxyferrocene in six synthetic steps in moderate yield with high diastereoselectivity.… Click to show full abstract
Abstract The synthesis of an unsymmetrical silyl-ether-modified 1-oxazolinyl 1,2′-bis(diphenylphosphine) ferrocene is proposed herein. The designed 1,2′-bisphosphine is generated from 1-bromo-l’-carboxyferrocene in six synthetic steps in moderate yield with high diastereoselectivity. Moreover, a 2,5-bisphosphine analog is afforded via the stepwise lithiation of chiral oxazolinyl ferrocene. A plausible ortho-metalation mechanism directed by the oxazoline moiety as a chiral-directed metalation group in stepwise lithiation is proposed.
Journal Title: Journal of Organometallic Chemistry
Year Published: 2019
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