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Abstract Synthesis of five Electron Withdrawing Group (EWG) activated Hoveyda-Grubbs’ catalysts containing thioperfluoroalkyl, sulfone and ketone functions is reported. The catalytic activity of these catalysts was well correlated with the… Click to show full abstract
Abstract Synthesis of five Electron Withdrawing Group (EWG) activated Hoveyda-Grubbs’ catalysts containing thioperfluoroalkyl, sulfone and ketone functions is reported. The catalytic activity of these catalysts was well correlated with the σp values of the Hammett constants for the respective EWGs. Importantly, one of new catalysts gave good results in synthesis of a macrocyclic precursor of anti-HCV agent BILN2061.
Keywords:
electron withdrawing;
grubbs catalysts;
sulfone ketone;
withdrawing group;
hoveyda grubbs;
activated hoveyda
Journal Title: Journal of Organometallic Chemistry
Year Published: 2020
Link to full text (if available)
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Journal Title: Journal of Organometallic Chemistry
Year Published: 2020
Link to full text (if available)
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recommendations!