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Biosynthesized Selenium nanoparticles as a new catalyst in the synthesis of quinazoline derivatives in pentacyclic system with docking validation as (TRPV1) inhibitor

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Abstract In recent years, a lot of benefits of Selenium have been discovered for humans, animals and chemical uses. Nano-Selenium was biosynthesized and characterized by using FTIR, UV/Vis., TEM/SAED, and… Click to show full abstract

Abstract In recent years, a lot of benefits of Selenium have been discovered for humans, animals and chemical uses. Nano-Selenium was biosynthesized and characterized by using FTIR, UV/Vis., TEM/SAED, and mapping to ensure their crystallinity. The N-bridged imidazo-quinazoline derivatives were successfully synthesized in pentacyclic nonlinear ortho fused polynuclear by a one-pot reaction of aldehyde, β-naphthol, and 2-aminobenzoimidazole in the presence of a catalytic amount of aqueous nano-Se as a highly efficient and facile catalyst at 70-80 °C. The molecular docking study as TRPV1 inhibitor compared with Rutaecarpine and Evodiamine as reference alkaloids ligands.

Keywords: catalyst; quinazoline derivatives; trpv1 inhibitor; selenium

Journal Title: Journal of Organometallic Chemistry
Year Published: 2021

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