Abstract A rhodium-catalyzed alcohol-mediated ortho-functionalization of 2-aryl-2H-indazoles through sequential C-H activation and carbenoid insertion with diazotized Meldrum's acid was developed. Using the 2H-indazole as the directing group and alcohol as… Click to show full abstract
Abstract A rhodium-catalyzed alcohol-mediated ortho-functionalization of 2-aryl-2H-indazoles through sequential C-H activation and carbenoid insertion with diazotized Meldrum's acid was developed. Using the 2H-indazole as the directing group and alcohol as the alkyl source, a series of ortho-alkylated aryl-2H-indazoles were obtained over a wide structural scope with high site-selectivity and excellent functional-group tolerance.
Keywords:
catalyzed directed;
rhodium catalyzed;
diazotized meldrum;
functionalization;
meldrum acid
Journal Title: Journal of Organometallic Chemistry
Year Published: 2021
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Journal Title: Journal of Organometallic Chemistry
Year Published: 2021
Link to full text (if available)
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recommendations!