Photo from wikipedia
HIGHLIGHTSRiboflavin‐5’‐phosphate precipitates in the presence of divalent cations.Cyclodextrins were probed as solubilizing agents for riboflavin‐5’‐phosphate.&bgr;‐cyclodextrin is the best solubilizing agent.A 1 to 2 riboflavin‐5’‐phosphate/&bgr;‐cyclodextrin complex is formed in solution. ABSTRACT… Click to show full abstract
HIGHLIGHTSRiboflavin‐5’‐phosphate precipitates in the presence of divalent cations.Cyclodextrins were probed as solubilizing agents for riboflavin‐5’‐phosphate.&bgr;‐cyclodextrin is the best solubilizing agent.A 1 to 2 riboflavin‐5’‐phosphate/&bgr;‐cyclodextrin complex is formed in solution. ABSTRACT Several cyclodextrins (CDs) were probed in order to counteract the precipitation of riboflavin‐5’‐phosphate (or flavin mononucleotide, FMN‐P) due to the presence of divalent cations, by exploiting Nuclear Magnetic Resonance (NMR) spectroscopy both for quantitative analyses and stereochemical characterizations. Among CDs, &bgr;‐cyclodextrin (&bgr;‐CD) showed the best solubilizing power in virtue of the formation of a 1–2 FMN‐P/&bgr;‐CD complex, the stereochemistry of which was ascertained by ROESY (Rotating‐frame Overhauser Enhanced SpectroscopY) measurements.
Journal Title: Journal of Pharmaceutical and Biomedical Analysis
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!