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Abstract A small library of compounds are synthesized and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37RV. Two compounds, -[(2′,4′-dinitrophenyl)sulphonyl]-4-(p-aminophenylsulphonylamino)-6-(2′-chlorophenyl)-pyrimidine-5-carboxamide F b and 2-hydrazino-4-(p-aminophenylsulphonylamino)-6-(2′-chlorophenyl)-pyrimidine-5-carboxamide D b were… Click to show full abstract
Abstract A small library of compounds are synthesized and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37RV. Two compounds, -[(2′,4′-dinitrophenyl)sulphonyl]-4-(p-aminophenylsulphonylamino)-6-(2′-chlorophenyl)-pyrimidine-5-carboxamide F b and 2-hydrazino-4-(p-aminophenylsulphonylamino)-6-(2′-chlorophenyl)-pyrimidine-5-carboxamide D b were found to be the most active compounds in vitro with MIC of 0.02 μg/mL against MTB and were more potent compared to isoniazid (MIC: 0.03 μg/mL).
Journal Title: Journal of Saudi Chemical Society
Year Published: 2017
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