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Synthesis and biological evaluation of fluorine substituted pyrazolo[4,3-e][1,2,4]triazines as purine analogues

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Abstract Some more new fluorine substituted pyrazolo[4,3-e][1,2,4]triazine derivatives (2 – 5) , 7 , 10 , 14 , 17 have been synthesized derived from hydrazinolysis of N-acyl/aroyl/dithioic formamido-2,3-dimethyl-1-phenyl-pyrazolo-5-ones which are… Click to show full abstract

Abstract Some more new fluorine substituted pyrazolo[4,3-e][1,2,4]triazine derivatives (2 – 5) , 7 , 10 , 14 , 17 have been synthesized derived from hydrazinolysis of N-acyl/aroyl/dithioic formamido-2,3-dimethyl-1-phenyl-pyrazolo-5-ones which are obtained from 4-aminoantipyrine 1 . The enzymatic assays (cellobaise activity) of the new products have been evaluated.

Keywords: fluorine substituted; biological evaluation; evaluation fluorine; substituted pyrazolo; synthesis biological

Journal Title: Journal of Saudi Chemical Society
Year Published: 2017

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