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Myopathy, athletism, pregnancy, race, and chromosomal defects need to be considered in noncompaction

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With interest we read the article by Asfalou et al. [1] about the clinical characteristics of 23 Moroccan patients with left ventricular hypertrabeculation/noncompaction (LVHT). We have the following comments and… Click to show full abstract

With interest we read the article by Asfalou et al. [1] about the clinical characteristics of 23 Moroccan patients with left ventricular hypertrabeculation/noncompaction (LVHT). We have the following comments and concerns. The proportion of men was higher than previously reported. Was this due to the fact that the study was carried out in a military hospital where usually more men than women are treated? Was it due to a selection bias? The percentage of patients presenting with left bundle branch block was high [1]. What is the explanation for this? Is it attributable to endocardial fibrosis, frequently found in LVHT? How many had heart failure and how many had systolic dysfunction? Was there a history of sudden cardiac death in any of the patients or their relatives? The proportion of patients with pulmonary hypertension is unexpectedly high (48%) [1]. This is in contrast to what has been reported thus far. How do the authors explain this high rate of pulmonary hypertension? Was it acute or chronic pulmonary hypertension? Was the prevalence of pulmonary disease increased in the cohort? What was the rationale to establish oral anticoagulation with vitamin K antagonists in 28% of the patients? Did those with a history of thromboembolism present with intertrabecular thrombi, atrial fibrillation, or severe heart failure? We do not agree that the study was the first to analyse prognostic factors of LVHT [1]. Several studies about prognosis, prognostic factors, and outcome have been published [2]. One of these studies identified advanced age, presence of a

Keywords: pulmonary hypertension; race chromosomal; noncompaction; myopathy athletism; athletism pregnancy; pregnancy race

Journal Title: Journal of the Saudi Heart Association
Year Published: 2018

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