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Highlights • In the 2019 American College of Sports Medicine Wolffe lecture George Brooks described history Lactate Shuttle development.• Lactate is a fuel energy source, the main gluconeogenic precursor, and… Click to show full abstract
Highlights • In the 2019 American College of Sports Medicine Wolffe lecture George Brooks described history Lactate Shuttle development.• Lactate is a fuel energy source, the main gluconeogenic precursor, and a signaling molecule with autocrine, paracrine, and endocrine functions.• Endurance training develops the capacities to produce, remove and utilize lactate.• Lactate is favored as a fuel by working red muscle, heart, liver, and brain. Clinical trials are under way to improve outcomes in traumatic brain injury patients using lactate supplementation.• The importance of Lactate Shuttle in normal physiology is emphasized by the realization that dysfunctional lactate shuttling is involved in cancer, metabolic inflexibility, and inflammation.
Journal Title: Journal of Sport and Health Science
Year Published: 2020
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