Highlights • The secretion of skeletal muscle FSTL1 was stimulated by dynamic resistance exercise.• FSTL1 from skeletal muscle supplemented the insufficiency of cardiac FSTL1, which promoted myocardial angiogenesis and protected… Click to show full abstract
Highlights • The secretion of skeletal muscle FSTL1 was stimulated by dynamic resistance exercise.• FSTL1 from skeletal muscle supplemented the insufficiency of cardiac FSTL1, which promoted myocardial angiogenesis and protected the heart from myocardial infarction.• Exogenous FSTL1 improved the proliferation and the small tubes formation ability of HUVECs.• FSTL1-DIP2A regulated angiogenesis mainly through the Smad2/3 but was not affected by TGFβR1.• FSTL1, DIP2A, Smad2/3, and fstl1 gene transcription formed a regulation mode of feedback loop.
Journal Title: Journal of Sport and Health Science
Year Published: 2020
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