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Marginal distribution test for checking proportional hazards model assumption

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Abstract Let Z be the covariate vector and Y be the response variable with the joint cumulative distribution function F Y , Z . Given a random sample from F… Click to show full abstract

Abstract Let Z be the covariate vector and Y be the response variable with the joint cumulative distribution function F Y , Z . Given a random sample from F Y , Z , in order to analyze the data based on a certain proportional hazards (PH) model, say Θ 0 , one needs to test the null hypothesis H 0 : F Y , Z ∈ Θ 0 first. The existing tests to achieve this task make use of the residuals and are invalid in certain situations, such as when F Y , Z is not from any PH model. To overcome this disadvantage, we propose a valid model checking test of H 0 . It is based on the weighted average of the difference between two estimators of the marginal distribution of the response variable: its non-parametric maximum likelihood estimator and its estimator under Θ 0 . This test is called the marginal distribution (MD) test. We give the theoretical justification of the MD test. The simulation study suggests that the MD test is always valid, whereas the existing tests may be invalid and they are often unlikely to reject the wrong PH model assumption when they are not valid.

Keywords: hazards model; test; proportional hazards; marginal distribution; distribution

Journal Title: Journal of Statistical Planning and Inference
Year Published: 2019

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