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Highlights • We investigate a kinetic model for the mevalonate pathway which includes inhibition effects and a sink of acetyl-CoA.• Of the enzymes in the pathway, upregulating HMG-CoA reductase has… Click to show full abstract
Highlights • We investigate a kinetic model for the mevalonate pathway which includes inhibition effects and a sink of acetyl-CoA.• Of the enzymes in the pathway, upregulating HMG-CoA reductase has the most significant positive effect on improving pathway efficiency.• Upregulating pyruvate dehydrogenase complex and HMG-CoA synthase can also help, but only in conjunction with the upregulation of HMG-CoA reductase.• We confirm our theoretical predictions by introducing the mevalonate pathway into Cupriavidus necator.
Keywords:
applying asymptotic;
hmg coa;
mevalonate pathway;
biology;
asymptotic methods
Journal Title: Journal of Theoretical Biology
Year Published: 2018
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Journal Title: Journal of Theoretical Biology
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!